Network view of active molecules. All active small molecules were clustered according to their ECFP_4 chemical fingerprints. Each node represents a unique small molecule: 1,802 small molecules cluster together and are shown here. Edges represent structural relatedness at a cutoff of ECFP_4 greater than 0.5. Core structural clusters are outlined and designated groups I to IV. Acute screen data were mapped onto the active network with white fitness inhibitors, red photosynthetic inhibitors, blue motility/phototaxis modulators, and green photosynthetic and motility/phototaxis; circles indicate fitness inhibition, diamonds indicate no fitness inhibition. Bar graphs: phenotypes for each chemical group are displayed as a percentage.