The combined methylation status of CNR1 , ACSS3 , HIST1H3C and PRPH can potentially discriminate HR patients. The Kaplan-Meier plot shows overall survival in the high-risk samples of the high-throughput MSP screening according to their predicted overall survival status based on leave-one-out decision tree analysis using the methylation data of CNR1, ACSS3, HIST1H3C and PRPH. Group 1 is predicted to survive, group 2 to die of disease. The P-value is determined using log-rank test (Mantel-Cox). Time is indicated in days, starting from diagnosis.