Figure 4

Gene bionetwork cluster analysis of 11 male and female tissues with corresponding genemodules. Topological overlap matrixes of the gene co-expression network consisting of genesdifferentially expressed in 11 tissues of the F3 vinclozolin lineage compared to F3 control lineageanimals. Genes in the rows and columns are sorted by an agglomerative hierarchical clusteringalgorithm. The different shades of color signify the strength of the connections between the nodes(from white signifying not significantly correlated to red signifying highly significantlycorrelated). The topological overlap matrix strongly indicates highly interconnected subsets ofgenes (modules). Modules identified are colored along both column and row and are boxed. (a)Matrixes of the combined network for six male tissues. (b) Matrixes of the combinednetwork for five female tissues. (c) Matrixes of the combined network for 11 male and femaletissues.