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Table 2 Uniformity of depth by three human exome capture platforms

From: Comprehensive comparison of three commercial human whole-exome capture platforms

  Filtered Mean coverage (×) Coverage depth (percent of bases in TR) Coverage depth (percent of bases in FR)
Replicatea Reads (M) Bases (Mb) On TR On FR 1× to 10× 10× to 50 × >50× 1× to 10× 10× to 50× >50×
NA-r1 25.5 2,280 30.8 9.3 1.3 12.3 69.8 16.6 6.8 56.2 36.8 0.2
NA-r2 27.1 2,421 30.0 8.5 1.0 11.2 73.8 14.1 7.4 53.1 33.1 0.1
NS-r1 26.1 2,338 30.1 10.8 1.7 13.0 69.7 15.6 6.1 53.1 39.5 1.3
NS-r2 25.5 2,289 30.3 9.9 1.5 13.6 68.5 16.3 6.7 56.4 35.8 1.0
AS-r1 25.7 2,222 32.7 3.5 2.1 18.6 59.5 19.8 46.8 42.7 10.1 0.4
AS-r2 25.1 2,175 32.5 3.4 2.2 19.0 59.0 19.8 47.3 42.4 9.9 0.4
  1. For the analyses, a set of data that has 30-fold coverage on targeted regions was randomly selected for each of the six replicates. aAS, Agilent solution; NA, NimbleGen array; NS, NimbleGen solution; r1 and r2 are two replicate experiments for each platform. FR, flanking region; TR, targeted region.