Table 3 The pathways statistically significant in the 3% most increased transcripts in PPARγ agonist-treated cells identified in the multivariate models
P-value | Pathway | Transcripts increased in PPARγ agonist-treated cells mapping to the pathway |
|---|---|---|
6.4e-05 | Glycolysis | Aldoa, Pgam1, Pfkl, Gapdh, Gpi1 |
1.1e-03 | Gluconeogenesis | Aldoa, Slc25a11, Pgam1, Gapdh, Gpi1 |
1.2e-03 | Ca2+ signaling via IP3 binding to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel | Itpr2, Itpr1 |
1.8e-03 | Phospholipase C-mediated signaling events | Prkaca, Itpr2, Itpr1, Adcy6, Pde1b |
2.5e-03 | Hormone-sensitive lipase-mediated triacylglycerol hydrolysis | Prkaca, Abhd5, Ppp1ca |
2.6e-03 | Metabolism of lipids and lipoproteins | Prkaca, Abhd5, Abcd3, Ppp1ca, Ncor1, Chd9, Slc27a1, Hsd17b4, Acaa2, Sin3b, Scd2, Hmgcl, Fads3, Csnk1g2, Angptl4 |
3.2e-03 | Regulation of insulin secretion | Prkaca, Dlst, Ndufb6, Itpr1, Gpi1, Aldoa, Ndufs6, Pgam1, Itpr2, Pfkl, Gapdh |
5.8e-03 | Formation of acetoacetic acid in the synthesis of ketone bodies | Hmgcl, Acaa2 |
8.2e-03 | Additional metabolism of carbohydrates | Aldoa, Slc25a11, Pgam1, Pfkl, Gapdh, Gpi1, G6pdx |
1.1e-02 | Protein kinase A-mediated events | Prkaca, Pde1b |
1.1e-02 | Regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha | Sin3b, Scd2, Fads3, Ncor1, Chd9, Slc27a1, Angptl4 |
1.7e-02 | Integration of energy metabolism | Prkaca, Dlst, Ndufb6, Gpi1, Aldoa, Ndufs6, Pgam1, Pfkl, Adcy6, Gapdh |
2.0e-02 | β-Oxidation of very long chain fatty acids | Abcd3, Hsd17b4 |
0.1e-02 | Peroxisomal lipid metabolism | Abcd3, Slc27a1, Hsd17b4 |