Figure 5

Developmentally dynamic domains are enriched in regulatory genes. (a) Density of DDEs plotted across chromosome 2R. Peaks in DDE density above a statistical background (dotted grey line) were labeled by associated gene name and colored by gene ontology (GO) category. (b) The median phastcons conservation score (and 95% confidence intervals) for all DDEs that map to non-coding locations is shown alongside the median and intervals calculated for randomly chosen non-coding sites within the genome. (c) DNaseI tag density across an approximately 30-kb region of chromosome 2R around ppa, indicated with an asterisk in (a,c), illustrating an exemplary developmentally dynamic domain composed of clustered DDEs (red arrows).