Skip to main content

Table 5 Concentrations of CMP, AMP, GMP, XMP, and TMP

From: Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidisand human cells

  Control 0.16 μM IQ-143 1.25 μM IQ-143
  Mean (μg/ml) SD Mean (μg/ml) SD % of control Mean (μg/ml) SD % of control
CMP 21.03 0.96 24.41* 0.24 116.07 3.86** 0.19 18.35
TMP 1.61 0.12 1.67 0.11 103.76 8.81* 0.24 547.20
AMP 0.42 0.06 0.12* 0.02 28.57 20.37** 0.80 4850.00
GMP 1.51 0.05 1.44** 0.05 95.36 3.66* 0.21 242.38
XMP 2.62 0.20 3.96** 0.16 151.15 3.44** 0.11 131.30
  1. Direct measurement of CMP, AMP, GMP, XMP, and TMP concentrations in S. aureus (in μg/ml and in percentage of control value depending on the applied IQ-143 concentration). Statistically significant differences are indicated (*P < 0.05,**P < 0.01). SD, standard deviation.