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Table 1 Gene expression changes measured after administration of IQ-143 in S. epidermidis RP62A

From: Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidisand human cells

  Gene expression after IQ-143 administration
Affected enzymes 0.00 μMa 0.16 μM 1.25 μM
OP_complex1 1.000 1.000 1.000
OP_complex2 1.000 1.000 1.000
OP_complex3 1.000 1.000 8.390
OP_complex4 1.000 1.000 1.000
OP_complex5a 1.000 1.000 1.000
SERP0290-zinc-transport_efflux 1.000 0.399 0.449
SERP0291-zinc-transporter_import 1.000 0.544 0.450
SERP0292-iron-dicitrate-transporter_import 1.000 0.544 0.430
SERP0389-EC:1.1.1.1-rn:R00754 1.000 1.000 3.070
SERP0653-EC:6.3.5.3-rn:R04463 1.000 1.000 0.491
SERP0655-EC:2.4.2.14-rn:R01072 1.000 1.000 0.436
SERP0656-EC:6.3.3.1-rn:R04208 1.000 1.000 0.424
SERP0657-EC:2.1.2.2-rn:R04325 1.000 1.000 0.426
SERP0658-EC:2.1.2.3-rn:R04560 1.000 1.000 0.439
SERP0659-EC:6.3.4.13-rn:R04144 1.000 1.000 0.392
SERP0686-spermidine/putrescine-transport_import 1.000 1.000 2.361
SERP0687-spermidine/putrescine-transport_import 1.000 1.000 2.208
SERP0688-spermidine/putrescine-transport_import 1.000 1.000 2.075
SERP0765-Uracil-permease-transport_import 1.000 1.000 2.765
SERP0831-EC:2.7.7.7-rn:R00375 1.000 1.000 2.202
SERP0831-EC:2.7.7.7-rn:R00376 1.000 1.000 2.202
SERP0831-EC:2.7.7.7-rn:R00378 1.000 1.000 2.202
SERP0831-EC:2.7.7.7-rn:R00379 1.000 1.000 2.202
SERP0841-EC:2.7.7.8-rn:R00437 1.000 1.000 2.867
SERP0841-EC:2.7.7.8-rn:R00439 1.000 1.000 2.867
SERP1403-MultiDrug-transport_efflux 1.000 1.000 2.063
SERP1802-cobalt/nickel-transport_efflux 1.000 1.000 2.401
SERP1803-cobalt/nickel-transport_efflux 1.000 1.000 2.301
SERP1944-MultiDrug-transport_efflux 1.000 1.000 2.075
SERP1951-lipoprotein-transport_efflux/import 1.000 1.000 0.457
SERP1952-macrolide-transport_efflux 1.000 1.000 0.386
SERP1997-formate/nitrite-transport_efflux/import 1.000 1.000 2.619
SERP2060-glyerol-transport_import 1.000 1.000 2.823
SERP2156-EC:1.1.1.27-rn:R00703 1.000 1.000 0.486
SERP2179-choline/betaine/carnitine-transp_efflux 1.000 7.071 2.389
SERP2186-EC:2.7.7.4-rn:R00529 1.000 1.000 0.349
SERP2283-phopsphonate-transport_import 1.000 1.000 2.680
SERP2289-MultiDrug-transport_efflux 1.000 1.000 1.971
  1. This table shows the gene expression changes measured after administration of IQ-143. 1.0 denotes the standard activity without IQ-143. A value of 0.5 indicates that the activity of this enzyme was halved after administration of IQ-143, a value of 2.075 indicates that the activity was doubled (again after administration of IQ-143). aExpression with no IQ-143 (0.00 μM column) is set to 1.000 for normalization purposes.