Table 1 Gene expression changes measured after administration of IQ-143 in S. epidermidis RP62A
Gene expression after IQ-143 administration | |||
|---|---|---|---|
Affected enzymes | 0.00 μMa | 0.16 μM | 1.25 μM |
OP_complex1 | 1.000 | 1.000 | 1.000 |
OP_complex2 | 1.000 | 1.000 | 1.000 |
OP_complex3 | 1.000 | 1.000 | 8.390 |
OP_complex4 | 1.000 | 1.000 | 1.000 |
OP_complex5a | 1.000 | 1.000 | 1.000 |
SERP0290-zinc-transport_efflux | 1.000 | 0.399 | 0.449 |
SERP0291-zinc-transporter_import | 1.000 | 0.544 | 0.450 |
SERP0292-iron-dicitrate-transporter_import | 1.000 | 0.544 | 0.430 |
SERP0389-EC:1.1.1.1-rn:R00754 | 1.000 | 1.000 | 3.070 |
SERP0653-EC:6.3.5.3-rn:R04463 | 1.000 | 1.000 | 0.491 |
SERP0655-EC:2.4.2.14-rn:R01072 | 1.000 | 1.000 | 0.436 |
SERP0656-EC:6.3.3.1-rn:R04208 | 1.000 | 1.000 | 0.424 |
SERP0657-EC:2.1.2.2-rn:R04325 | 1.000 | 1.000 | 0.426 |
SERP0658-EC:2.1.2.3-rn:R04560 | 1.000 | 1.000 | 0.439 |
SERP0659-EC:6.3.4.13-rn:R04144 | 1.000 | 1.000 | 0.392 |
SERP0686-spermidine/putrescine-transport_import | 1.000 | 1.000 | 2.361 |
SERP0687-spermidine/putrescine-transport_import | 1.000 | 1.000 | 2.208 |
SERP0688-spermidine/putrescine-transport_import | 1.000 | 1.000 | 2.075 |
SERP0765-Uracil-permease-transport_import | 1.000 | 1.000 | 2.765 |
SERP0831-EC:2.7.7.7-rn:R00375 | 1.000 | 1.000 | 2.202 |
SERP0831-EC:2.7.7.7-rn:R00376 | 1.000 | 1.000 | 2.202 |
SERP0831-EC:2.7.7.7-rn:R00378 | 1.000 | 1.000 | 2.202 |
SERP0831-EC:2.7.7.7-rn:R00379 | 1.000 | 1.000 | 2.202 |
SERP0841-EC:2.7.7.8-rn:R00437 | 1.000 | 1.000 | 2.867 |
SERP0841-EC:2.7.7.8-rn:R00439 | 1.000 | 1.000 | 2.867 |
SERP1403-MultiDrug-transport_efflux | 1.000 | 1.000 | 2.063 |
SERP1802-cobalt/nickel-transport_efflux | 1.000 | 1.000 | 2.401 |
SERP1803-cobalt/nickel-transport_efflux | 1.000 | 1.000 | 2.301 |
SERP1944-MultiDrug-transport_efflux | 1.000 | 1.000 | 2.075 |
SERP1951-lipoprotein-transport_efflux/import | 1.000 | 1.000 | 0.457 |
SERP1952-macrolide-transport_efflux | 1.000 | 1.000 | 0.386 |
SERP1997-formate/nitrite-transport_efflux/import | 1.000 | 1.000 | 2.619 |
SERP2060-glyerol-transport_import | 1.000 | 1.000 | 2.823 |
SERP2156-EC:1.1.1.27-rn:R00703 | 1.000 | 1.000 | 0.486 |
SERP2179-choline/betaine/carnitine-transp_efflux | 1.000 | 7.071 | 2.389 |
SERP2186-EC:2.7.7.4-rn:R00529 | 1.000 | 1.000 | 0.349 |
SERP2283-phopsphonate-transport_import | 1.000 | 1.000 | 2.680 |
SERP2289-MultiDrug-transport_efflux | 1.000 | 1.000 | 1.971 |