Figure 1From: Bringing order to protein disorder through comparative genomics and genetic interactionsGenetic interactions distinguish different roles of disorder. (a) Percentage of disordered residues of yeast proteins by their number of GIs. (b) Multi-functionality (see Materials and methods) for disordered and structured GI hubs and non-hubs. Hubs are genes in the top 90th percentile (above 90 interactions) of GIs while non-hubs are in the bottom 50th percentile (below 15 interactions). (c) Evolutionary constraint on sequence (dN/dS ratio) on hubs and non-hubs. In both cases disordered proteins have a significantly higher dN/dS than structured proteins. (d) Evolutionary constraint measured by the presence of orthologs in other yeast species (phylogenetic persistence). While disordered non-hubs are less conserved than structured non-hubs, the disordered hubs are as conserved as structured hubs. P-values were computed with a Wilcoxon test, and error bars represent boot-strapped 95% confidence intervals.Back to article page