Figure 2

Profiles of charge, folding energy, and co-adaptation between codon bias and the tRNA pool for genes with high and low ribosomal density. (a-c) Profiles of charge (a), folding energy (b) and co-adaptation between codon bias and the tRNA pool (c) for genes with high ribosomal density (red; top 10%) and genes with low ribosomal density (green; bottom 10%) in S. cerevisiae. (d-f) Profiles of charge (d), folding energy (e) and co-adaptation between codon bias and the tRNA pool (f) for genes with high (mRNA levels) × (Ribosomal density) (red; top 10%) and genes with low (mRNA levels) × (ribosomal density) (green; bottom 10%) in S. cerevisiae. The ramps and corresponding P-values are shown in the figure. Similar graphs were obtained for E. coli and C. elegans (see graphs and corresponding P-values in Figures S4 and S5 in Additional file 2).