Figure 3

The mode of interaction of TIMP1 and the catalytic domain of MMP3. (a) Ribbon diagram of the complex involving TIMP1 (red) and MMP3 (blue). Zinc and calcium ions are shown as pink and blue spheres, respectively. The disulfide bonds of TIMP1 are shown in yellow. This image was prepared from the Brookhaven Protein Data bank entry (1UEA) using PyMol [24]. (b) Schematic representation of the amino-terminal ridge of TIMP1, which interacts with the active site of the MMP. Reproduced from [23] with permission from Springer Science+Business Media.