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Figure 3 | Genome Biology

Figure 3

From: Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

Figure 3

Cancer-related genes affected by rearrangements breakpoints. (a) Disruption of EXO1 and FH (fumarate hydratase) by rearrangement breakpoints in a metastasis-specific cluster on chromosome 1 in patient 3. (b) Disruption of MYCBP2 by a rearrangement breakpoint in a cluster on chromosome 13 in patient 1. Genes from the Cancer Genome Census are also depicted for this cluster. (c) Disruption of SORBS2 by metastasis-specific deletions in patients 2 and 4. (d) Disruption of CSMD1 by a metastasis-specific deletion in patient 2.

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Genome Biology

ISSN: 1474-760X

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