From: Revealing the molecular signatures of host-pathogen interactions
Pathogen | Phenotype | Gene | N cases/controls | Effect size | P-value | References |
---|---|---|---|---|---|---|
Dengue virus | Severe dengue | MICB | 3, 742/4, 952 | 1.34 | 4.41 × 10-11 | [20] |
 | Severe dengue | PLCE1 | 3, 742/4, 952 | 0.80 | 3.08 × 10-10 | [20] |
N. meningitidis a | Meningococcal disease | CFH | 1, 443/6, 079 | 0.64 | 2.2 × 10-11 | [7] |
P. falciparum a | Severe malaria | ABO | 3, 906/5, 489 | 1.20 | 2.0 × 10-7 | |
 | Severe malaria | HBB | 2, 045/3, 758 | 0.63 | 3.7 × 10-11 | [62] |
M. leprae | Leprosy | NOD2 | 3, 960/7, 180 | 1.59 | 3.77 × 10-40 | [5] |
 |  | RIPK2 | 3, 960/7, 180 | 0.76 | 1.38 × 10-16 | [5] |
 |  | HLA-DR | 3, 960/7, 180 | 0.67 | 5.35 × 10-27 | [5] |
 |  | TNFSF15 | 3, 960/7, 180 | 1.37 | 3.39 × 10-21 | [5] |
 |  | C13orf31-CCDC122 | 3, 960/7, 180 | 1.68 | 3.72 × 10-54 | [5] |
M. tuberculosis | Tuberculosis | - | 3, 632/7, 501 | 1.19 | 6.8 × 10-9 | [63] |
HIV | Viral set pointa | HLA-B | 486 | 9.6% | 9.36 × 10-12 | [6] |
 | Viral set pointa | HLA-C | 486 | 6.5% | 3.77 × 10-9 | [6] |
HBV | Chronic infection | HLA-DP | 2, 086/4, 301 | 1.75 | 6.34 × 10-39 |