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Figure 4 | Genome Biology

Figure 4

From: Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility

Figure 4

Re-wiring of the Lgr5 hair follicle eQTL network. (a) Gene expression levels of Krt71, Krt25, Msx2, and Lgr5 in skin, papillomas, and carcinomas, showing that while Lgr5 is significantly correlated with Msx2 and Krt71 in normal skin, this association is lost during tumor progression. (b) A new eQTL network for hair follicle keratins in papillomas where the locus affects Gprc5d (yellow node) in cis and other genes (blue nodes) in trans. Green lines indicate significant influence of eQTL locus on all genes in the network (≤10% FDR); grey lines indicate significant gene-gene correlation.

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Genome Biology

ISSN: 1474-760X

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