Volume 11 Supplement 1
Reconstructing sex chromosome evolution
© Page et al; licensee BioMed Central Ltd. 2010
Published: 11 October 2010
The mammalian X and Y chromosomes evolved from an ordinary pair of autosomes that existed in a reptilian ancestor that probably relied on temperature-dependent sex determination, as in crocodiles today. Independently and concurrently, the avian Z and W chromosomes (ZZ males, ZW females) evolved from a different pair of autosomes that was present in the same ancestor. Both the mammalian XY pair and the avian ZW pair have emerged with specialized and disproportionate roles in germ cell development. These germ cell specializations are best understood in the mammalian Y chromosomes and are only now being appreciated in the mammalian X chromosomes and the avian ZW pair.
To reconstruct and better understand nature's sex chromosome experiment, we have set out to comprehensively sequence and compare the sex chromosomes of four primates, two rodents, an ungulate, a marsupial and a bird. I will describe insights that have emerged from this ongoing effort.
- Reijo , et al: . Nature Genetics. 1995, 10: 383-10.1038/ng0895-383.PubMedView ArticleGoogle Scholar
- Saxena , et al: . Nature Genetics. 1996, 14: 292-10.1038/ng1196-292.PubMedView ArticleGoogle Scholar
- Lahn & Page: . Science. 1997, 278: 675-10.1126/science.278.5338.675.PubMedView ArticleGoogle Scholar
- Lahn & Page: . Science. 1999, 286: 964-10.1126/science.286.5441.964.PubMedView ArticleGoogle Scholar
- KurodaKawaguchi , et al: . Nature Genetics. 2001, 29: 279-10.1038/ng757.View ArticleGoogle Scholar
- Wang , et al: . Nature Genetics. 2001, 27: 422-10.1038/86927.PubMedView ArticleGoogle Scholar
- Skaletsky , et al: . Nature. 2003, 423: 825-10.1038/nature01722.PubMedView ArticleGoogle Scholar
- Rozen , et al: . Nature. 2003, 423: 873-10.1038/nature01723.PubMedView ArticleGoogle Scholar
- Mueller , et al: . Nature Geneticss. 2008, 40: 794-10.1038/ng.126.View ArticleGoogle Scholar
- Lange , et al: . Cell. 2009, 138: 855-10.1016/j.cell.2009.07.042.PubMedPubMed CentralView ArticleGoogle Scholar
- Hughes , et al: . Nature. 2010, 463: 536-10.1038/nature08700.PubMedPubMed CentralView ArticleGoogle Scholar
- Bellott , et al: . Nature. 2010, 466: 612-10.1038/nature09172.PubMedPubMed CentralView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd.