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  • Invited speaker presentation
  • Open Access

Reading and writing genomes

  • 1
Genome Biology201011 (Suppl 1) :I2

https://doi.org/10.1186/gb-2010-11-s1-i2

  • Published:

Keywords

  • Stem Cell
  • Immune Response
  • Human Genome
  • Global Health
  • Pluripotent Stem Cell

The human genome draft published in 2004 was a milestone, but achieved at a cost of $3 billion it is inapplicable to diagnostics for global health. We have reduced the cost of sequencing by over a million times in the past six years. The next step is integrating Genome + Environment = Trait (GET) data on large diverse cohorts enabled by a new consent mechanism (http://www.personalgenomes.org) in a globally shareable, unrestricted form (http://evidence.personalgenomes.org). This includes time-series studies of microbiomes and immune responses to such microbes, allergens, vaccines and allele-specific expression in pluripotent stem cells. To move from correlations to causations and cures requires a similar million-fold improvement in DNA writing technology - via use of DNA synthesized on chips and Multiplex Automated Genome Engineering (MAGE). Applications include metabolic engineering and multivirus resistant cells.

Authors’ Affiliations

(1)
Harvard Medical School, NRB Rooms 232 & 238, 77 Ave Louis Pasteur, Boston, MA 02115, USA

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