Figure 6

Coordination of RNA and protein turnover. (a) Groups of genes with actively translated or translationally silent mRNAs in early Drosophila embryos were recovered from a genome-wide ribosomal profiling study [68]. Enrichment analyses (Fisher's exact test) were performed to address the correlation between translation rate and RNA stability. Odds ratios (enrichments and depletions) within transcript classes (Figure 3; II-V, union of classes II to V) are shown on a log2 scale (y-axis); color code is as in Figure 5; significance of enrichments are indicated by multiple testing corrected P-values (q-values). (b) A recent proteomics screen identified up- and down-regulated proteins in early fly embryos [69]. Enrichment analyses were performed to address the correlation between protein level changes and RNA stability. Note that RNA decay is negatively correlated with active translation and protein up-regulation.