Table 1 Characterized rat genetic knockout models
From: Rat traps: filling the toolbox for manipulating the rat genome
Knocked out gene | Technology | Involvement | Biological implication | References |
|---|---|---|---|---|
Brca2 | ENU mutagenesis | DNA repair | Tumorigenesis | |
Apc | ENU mutagenesis | Wnt signaling | Tumorigenesis | [48] |
Msh6 | ENU mutagenesis | DNA repair | Tumorigenesis | [49] |
Il2rg | ZFN-mediated gene targeting | Immune response | Immunology | [60] |
Sert | ENU mutagenesis | Emotion, motivation and cognition | Complex behavior | [67] |
Pmch | ENU mutagenesis | Bodyweight regulation | Complex behavior | [68] |
Mc4r | ENU mutagenesis | Bodyweight regulation | Complex behavior | [69] |