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Table 1 Characterized rat genetic knockout models

From: Rat traps: filling the toolbox for manipulating the rat genome

Knocked out gene Technology Involvement Biological implication References
Brca2 ENU mutagenesis DNA repair Tumorigenesis [47, 66]
Apc ENU mutagenesis Wnt signaling Tumorigenesis [48]
Msh6 ENU mutagenesis DNA repair Tumorigenesis [49]
Il2rg ZFN-mediated gene targeting Immune response Immunology [60]
Sert ENU mutagenesis Emotion, motivation and cognition Complex behavior [67]
Pmch ENU mutagenesis Bodyweight regulation Complex behavior [68]
Mc4r ENU mutagenesis Bodyweight regulation Complex behavior [69]
  1. ENU, N-ethyl-N-nitrosourea; ZFN, zinc-finger nuclease.