Figure 2
From: Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action
Compound clusters, extracted from genome-wide two-way clustering on the complete dataset (using all genes and all compounds). (a) Antifungal azoles in the heterozygous data, with high structural similarity. All induce sensitivity in strains deleted for ERG11, an azole target, and related pleiotropic drug resistance (PDR) transport-related genes; fluconazole (inset) did not appear in this cluster, though it is also thought to target Erg11. (b) Psychoactive compounds that target dopamine, serotonin, and acetylcholine receptors in human; these compounds cluster in the heterozygous dataset based on inhibition of small ribosomal subunit genes and Cox17, potential targets in both yeast and human. (c) Examples of drugs with similar homozygous fitness profiles; the similarity is due to shared sensitivity of strains deleted for multi-drug resistance (MDR) genes with roles in vesicle-mediated transport.