|
CDS disrupted gene
|
GPR33
|
SERPINB11
|
TAAR9
|
|---|
|
Disruptive mutationb
|
Cga (R) → Tga
|
Gaa (E) → Taa
|
Aaa (K) → Taa
|
|
dbSNP ID
|
rs17097921
|
rs4940595
|
rs2842899
|
|
Genomic location
|
chr14-:31,022,505
|
chr18+:59,530,818
|
chr6+:132,901,302
|
|
Disrupted codon positionc
|
140 (332)
|
89 (388)
|
61 (344)
|
|
Reference allele in human
|
T
|
T
|
T
|
|
Reference allele in other primatesd
|
C
|
T
|
T
|
|
Test statistic for HWE in the meta-populatione
|
0.285 (P = 0.867)
|
8.659 (P = 0.013)
|
0.071 (P = 0.965)
|
- aSee Table S4 in Additional file 1 for allele frequency information. bBoth codons before and after the mutation (→) are shown with the affected base capitalized. The amino acid residue encoded by the codon is given in parentheses. cThe disrupted codon position in the coding sequence (CDS). The number of codons in the CDS is given in parentheses. dWidely regarded as the ancestral allele. Other primates currently include chimp, orangutan, and macaque. eThe χ2 goodness-of-fit test is used to test for the Hardy-Weinberg equilibrium (HWE) in the meta-population using the pooled genotype and allele frequency data.
