Figure 1
From: Genomic features defining exonic variants that modulate splicing
Proportion of variants with gains or losses in exonic splicing regulatory sequence with significant differences between splice-affecting genome variants and HapMap SNPs. SAVs were characterized by (a) the loss of ESEs and (b) the gain of ESSs. As a comparison, ESEfinder, Ast-ESR and PESE losses are also included. These were not significantly different between SAVs and hSNPs. Z score P-values from random bootstrap sampling relating to each type of change are located on the right of the histogram.