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Table 2 KEGG pathways enriched in the set of genes represented in modular subnetworks

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

KEGG pathway P-value
Ribosome 2.17E-27
Metabolic pathways 2.70E-15
Proteasome 2.33E-10
Pyrimidine metabolism 1.34E-09
Purine metabolism 7.08E-07
DNA replication 1.54E-06
Nucleotide excision repair 1.81E-05
Aminoacyl-tRNA biosynthesis 2.80E-05
Cell cycle 4.37E-05
Glutamate metabolism 1.54E-04
Glycolysis/gluconeogenesis 2.97E-04
Citrate cycle (TCA cycle) 5.41E-04
Methionine metabolism 1.25E-03
Ubiquitin mediated proteolysis 7.19E-03
Pyruvate metabolism 7.27E-03
Base excision repair 7.38E-03
Glyoxylate and dicarboxylate metabolism 7.39E-03
Arginine and proline metabolism 8.35E-03
Glycine, serine and threonine metabolism 8.38E-03
Pentose phosphate pathway 1.23E-02
Valine, leucine and isoleucine biosynthesis 1.30E-02
One carbon pool by folate 1.30E-02
RNA polymerase 1.76E-02
Alanine and aspartate metabolism 1.76E-02
Non-homologous end-joining 2.15E-02
Selenoamino acid metabolism 2.17E-02
Mismatch repair 2.20E-02
  1. All categories shown are significant at P < 0.05 after an FDR correction for multiple testing. KEGG pathways written in italics are also enriched for known longevity genes (Additional file 4).