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Table 2 KEGG pathways enriched in the set of genes represented in modular subnetworks

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

KEGG pathway

P-value

Ribosome

2.17E-27

Metabolic pathways

2.70E-15

Proteasome

2.33E-10

Pyrimidine metabolism

1.34E-09

Purine metabolism

7.08E-07

DNA replication

1.54E-06

Nucleotide excision repair

1.81E-05

Aminoacyl-tRNA biosynthesis

2.80E-05

Cell cycle

4.37E-05

Glutamate metabolism

1.54E-04

Glycolysis/gluconeogenesis

2.97E-04

Citrate cycle (TCA cycle)

5.41E-04

Methionine metabolism

1.25E-03

Ubiquitin mediated proteolysis

7.19E-03

Pyruvate metabolism

7.27E-03

Base excision repair

7.38E-03

Glyoxylate and dicarboxylate metabolism

7.39E-03

Arginine and proline metabolism

8.35E-03

Glycine, serine and threonine metabolism

8.38E-03

Pentose phosphate pathway

1.23E-02

Valine, leucine and isoleucine biosynthesis

1.30E-02

One carbon pool by folate

1.30E-02

RNA polymerase

1.76E-02

Alanine and aspartate metabolism

1.76E-02

Non-homologous end-joining

2.15E-02

Selenoamino acid metabolism

2.17E-02

Mismatch repair

2.20E-02

  1. All categories shown are significant at P < 0.05 after an FDR correction for multiple testing. KEGG pathways written in italics are also enriched for known longevity genes (Additional file 4).