Figure 3

Modular subnetworks are highly conserved across studies. Modular subnetworks m1 to m5 are shown in green and regular subnetworks r1 to r5 in blue. Bar height shows the percentage overlap across studies for seed genes of significant modular and regular subnetworks derived from the data in Golden et al. [2] and Budovskaya et al. [21]; this is calculated as the size of the intersection of sets of significant seed genes from both studies, divided by the union. P-values above each bar show the significance of the overlap calculated using the hypergeometric test.