Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats

Table 1 Number of differentially expressed probe sets in the iP vs P.NP Comparison

	Nucleus accumbens	Amygdala	Frontal cortex	Hippo-campus	Caudate putamen	At least one brain region	Multiple brain regions	Combined regions
Significant cis-regulated probe sets
Total	72	74	78	89	82	157	104	141
Single brain region only	11	8	7	10	17
Only significant in combined								19
Significant trans-regulated probe sets
Total	14	7	16	17	54	85	10	206
Single brain region only	9	2	8	10	46
Only significant in combined								143

Cis-regulated probe sets are those located in the chromosome 4 QTL interval; trans-regulated probe sets are located in the remainder of the genome. The first five columns show the number of cis- and trans-regulated probe sets that differ between iP and P.NP in each individual brain region. 'At least one brain region' shows the total number of unique probe sets that differed in one or more regions. 'Multiple brain regions' shows the total number of unique probe sets that differed in at least two of the five brain regions. 'Average expression' shows probe sets that differ when the average expression across the five regions in each animal was analyzed. 'Single brain region only' shows the number of unique probe sets significant in only that brain region. 'In average only' shows unique probe sets that were significant only in analysis of the average level of expression across the five regions in each animal.

ISSN: 1474-760X