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Table 2 Top categories of general molecular types

From: Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing

General molecular function

Number of genes

Examples

LOH genes

  

   Enzyme

80

USP26, INPP5K, PTPRS, MAT2B

   Kinase

25

CDK7, DGKE, MAP2K4, PDGFRL

   Transporter

21

ATP2B3, SLC36A3, SIL1, ABCA7

   Transcription regulator

20

BRCA1, FOXD4, SOX5, VEZF1

   G-protein coupled receptor

19

GPR174, OR1A2, TAS2R7, GRM6

   Transmembrane receptor

9

SEMA5A, IL31RA, ITGB3, OSMR

   Cytokine

7

IL3, ERBB2IP, EDA, CXCL16

   Ion channel

6

CCT8L2, CNGA2, GABRA6, GRIN3B

ASE genes

  

   Enzyme

18

MGMT, PLCH1, GUCY1A3, PYGL

   Transcription regulator

7

CTBP2, SMARCA4, BCLAF1, SPEN

   Kinase

6

FGFR2, FGFR4, IP6K2, TAOK1

   Transporter

5

SLC44A5, SLC25A5, SNX15, LBP

   Transmembrane receptor

3

HLA-DQA1, HLA-A, TNFRSF10D

   G-protein coupled receptor

2

ADORA1, GPR107

  1. Genes are binned exclusively into each category based on their primary molecular function terms. LOH, loss of heterozygosity; ASE, allele-specific expression.
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Genome Biology

ISSN: 1474-760X

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