Table 3 Genes essential for mitochondrial translation

Genes encoding mitochondrial ribosomal proteins

YBL090W/MRP21; YBR146W/MRPS9; YBR251W/MRPS5; YBR282W/MRPL27; YCR003W/MRPL32; YCR071C/IMG2; YDL045W-A/MRP10; YDR115W; YDR337W/MRPS28; YDR347W/MRP1; YEL050C/RML2; YER050C/RSM18; YGL129C/RSM23; YGR076C/MRPL25; YGR215W/RSM27; YGR220C/MRPL9; YHR147C/MRPL6; YJL063C/MRPL8; YJL096W/MRPL49; YKL003C/MRP17; YKL138C/MRPL31; YKL155C/RSM22; YKL170W/MRPL38; YKR006C/MRPL13; YKR085C/MRPL20; YLR312W-A/MRPL15; YLR439W/MRPL4; YMR158W/MRPS8; YMR188C/MRPS17; YMR193W/MRPL24; YMR286W/MRPL33; YNL081C/SWS2; YNL177C/MRPL22; YNL185C/MRPL19; YNL252C/MRPL17; YNR037C/RSM19; YOR150W/MRPL23; YOR158W/PET123; YPL173W/MRPL40

Other genes encoding known proteins

   *YBL019w

APN2

Class II abasic (AP) endonuclease involved in repair of DNA damage

   *YBR179c

FZO1

Transmembrane GTPase required for mitochondrial fusion

   YDL044c

MTF2

Mitochondrial protein involved in mRNA splicing and protein synthesis

   *YDR194c

MSS116

Mitochondrial RNA helicase, required for splicing of group II introns

   *YDR296w

MHR1

Involved in repair, recombination and maintenance of mitochondrial DNA

   *YER145c

FTR1

Iron permease that mediates high-affinity iron uptake

   *YER154w

OXA1

Component of the mitochondrial protein export machinery

   *YGL071w

RCS1

Transcription factor regulates genes involved in iron uptake and cell size

   YGL143c

MRF1

Mitochondrial peptide chain release factor

   YGR171c

MSM1

Met-tRNA synthetase, mitochondrial

   YHL038c

CBP2

Mitochondrial splicing factor

   YHR011w

DIA4

tRNA synthetase, may be involved in mitochondrial function

   YHR038w

RRF1

Mitochondrial ribosome recycling factor

   *YHR051w

COX6

Cytochrome c oxidase subunit VI

   YHR091c

MSR1

Arginyl-tRNA synthetase of mitochondria

   *YHR120w

MSH1

Involved in mitochondrial DNA repair

   YJL102w

MEF2

Mitochondrial translation elongation factor

   *YJL209w

CBP1

Required for COB mRNA stability or 5' processing

   *YJR144w

MGM101

Mitochondrial genome maintenance protein

   *YKL016c

ATP7

ATP synthase subunit d

   *YKL134c

OCT1

Mitochondrial intermediate peptidase

   YKL194c

MST1

Mitochondrial threonyl tRNA synthase

   YLR067c

PET309

Specific translational activator for the COX1 mRNA

   YLR069c

MEF1

Mitochondrial translation elongation factor G

   *YLR070c

XYL2

Xylitol dehydrogenase

   YLR139c

SLS1

Protein involved in mitochondrial metabolism

   *YLR295c

ATP14

ATP synthase subunit h

   YMR064w

AEP1

Required for accumulation of transcript of ATP9/OLI1

   *YMR089c

YTA12

Involved in proteolytic and chaperone activities in the inner membrane

   YMR097c

MTG1

Likely functions in assembly of the large ribosomal subunit

   *YMR098c

ATP25

Required for the stability of ATP9 mRNA

   *YMR267w

PPA2

Inorganic pyrophosphatase, mitochondrial

   *YMR287c

DSS1

RNase, associates with the ribosome, turnover of aberrant RNAs

   YNL073w

MSK1

Lysyl-tRNA synthetase, mitochondrial

   YOL033w

MSE1

Glutamyl-tRNA synthetase, mitochondrial

   *YOR065w

CYT1

Cytochrome c₁

   YOR187w

TUF1

Translation elongation factor Tu, mitochondrial

   YPL097w

MSY1

Tyrosyl-tRNA synthetase, mitochondrial

   YPL104w

MSD1

Aspartyl-tRNA synthetase, mitochondrial

   *YPL148c

PPT2

Activates mitochondrial acyl carrier protein

   *YPL254w

HFI1

Component of the ADA complex

   *YPL271w

ATP15

Epsilon subunit of F₁-ATP synthase

ORFs encoding unknown proteins

   *YDR065w

RRG1

Unknown function, protein is detected in highly purified mitochondria

   *YDR114c

Dubious ORF, overlaps with YDR115w

   *YGR102c

Unknown function, protein is detected in highly purified mitochondria

   *YGR150c

RRG2

Unknown function, protein is detected in highly purified mitochondria

   *YMR293c

RRG6

Unknown function, protein is detected in highly purified mitochondria

   *YNL184c

Dubious ORF unlikely to encode a protein

   *YPR116w

RRG8

Unknown function, GFP-tagged protein in mitochondria