Evolutionary rates and centrality in the yeast gene regulatory network

Table 1 Multiple regression of genomic variables and protein evolutionary rates

	dN		dN/dS		dN/dS'		Residuals dN-dS
Predictor	YTN1	YTN2	YTN1	YTN2	YTN1	YTN2	YTN1	YTN2
Relationships between evolutionary rates and six predictor variables
Expression level	-0.105	-0.022	-0.043	0.058	-0.051	0.061	-0.038	0.050
Expression variability	-0.047	-0.064	-0.010	-0.015	-0.011	-0.013	-0.019	-0.024
CAI	-0.096	-0.037	0.026	-0.060	-0.088	-0.046	-0.072	-0.055
GO	-0.135*	-0.277^†	-0.149*	-0.311^‡	-0.165^†	-0.313^‡	-0.168^†	-0.307^‡
Essentality	-0.185^†	-0.104	-0.229^‡	-0.121	-0.208^‡	-0.122	-0.181^†	-0.121
Centrality	0.162^†	0.199*	0.151*	0.191*	0.164^†	0.190*	0.164^†	0.201*
Relationships between evolutionary rates and seven predictor variables
Expression level	-0.107	-0.030	-0.044	0.047	-0.053	0.050	-0.040	0.041
Expression variability	-0.053	-0.084	-0.016	-0.036	-0.020	-0.035	-0.028	-0.043
CAI	-0.111	-0.059	0.010	-0.083	-0.105	-0.069	-0.091	-0.077
GO	-0.113	-0.204*	-0.129*	-0.244^†	-0.142*	-0.246^†	-0.145*	-0.237^†
Essentiality	-0.177^†	-0.039	-0.222^‡	-0.060	-0.199^†	-0.062	-0.173^†	-0.057
k_in	0.139*	0.291^†	0.132*	0.288^†	0.148*	0.288^†	0.152*	0.290^†
k_out	0.042	-0.165	0.032	-0.148	0.037	-0.147	0.031	-0.154

Network, function and expression-related variables have independent effects on the rate of protein evolution. Entries show standardized regression coefficients. *P < 0.05, ^†P < 0.01, ^‡P < 0.001.

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