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Table 4 Summary of signaling modules

From: Integrated analysis of breast cancer cell lines reveals unique signaling pathways

  Number of rules Key component(s) Summary of key events
1 1 Pi3k, ErbB4 ErbB4 activation of Pi3k
2 1 Snca Pyk2 activation of Snca
3 1 Caml, Rsk Rsk activation of Caml
4 1 Stat3 Stat3 activation by EgfR
5 1 Irs, Pi3k Irs activation of Pi3k
6 1 Rela Formation of Ikba, Nfkb1, Rela complex
7 2 Pik3ca-mut Akt signaling through Pi3k mutant
8 2 Mef2c Camk activation of Mef2c
9 2 IL11R, Jak IL11R activation of Jak
10 2 Elmo, Rac1 Elmo activation of Rac1
11 2 Abi1, Pir121 Wave1 activation dependent on Abi1 and Pir121
12 3 Mylk Mylk activation of Mlc
13 3 RhoB RhoB activation
14 3 EsR1, Bcat EsR1 activation by Rsk; Bcat activation
15 3 Fos Fos activation by Erk
16 3 Bcat Activation and degradation of Bcat
17 4 Cav1, UpaR Integrin/Cav1 activation of Shc; UpaR activation
18 5 Pten, Kras, Pik3ca Mutation rules
19 5 ErbB4 ErbB4 activation of ErbB2, Shc; Grb2 relocation
20 6 PrlR PrlR signaling
21 7 Irs1 Irs1 activation; Grb2 translocation
22 8 Pi3k Eight ways to activate Pi3k
23 12 RhoB RhoB activation of first-order effectors
24 12 Cbl Cbl-related signaling, including Rap1a, Crk, Dock
25 14 Src Src-related signaling, including Fak, Pax, Cas
26 15 EgfR First-order EgfR interactions including ErbB2, Grb2, Cbl
27 16 Efna1 EphA2/Efna1 signaling; Integrin deactivation by EphA2
28 27 ErbB3 ErbB3 activation by Nrg1 and ErbB2; ErbB3 activation of Shc
29 32 EgfR, Src Src-dependent activation of EgfR; Cdc42 signaling; activation of Src effectors
30 76 Src, Rac1-GTP Rac1 signaling; MAPK activation