Figure 4

The network models cluster into basal, luminal and mixed groups of cell lines. Heatmap shows the network features that varied across the cell line network models. Each column represents data from one network model; each row represents data for one network feature (component in the initial state, rule or component that underwent a state-change). Red indicates the component is present in the cell line; green indicates it is absent. Hierarchical clustering along the vertical dimension reveals that the networks form basal, luminal and mixed clusters. Hierarchical clustering along the horizontal dimension yields 30 signaling modules, each of which represents a small subnetwork. Signaling modules of particular interest, along with the key components in the initial state, are noted along the right side.