Figure 1
From: A computational approach for genome-wide mapping of splicing factor binding sites
Schematic representation of the COS(WR) function. (a) A candidate human sequence is queried with a regulatory motif. (b) The weighted rank (WR) is computed only for significant positions by combining all scores above the suboptimal threshold in a sequence window of size w. (c, d) We calculate WR scores for the candidate's homologous region in mouse that aligns to the human sequence flanking the significant hits. (e) WR scores of the candidate sequence and its homologue are combined by calculating the Conservation Of Score (COS).