Table 1 List of top hits from computational analysis of mean cell area in images from a high-content genome-wide RNAi screen
Sos | SOS1 | -4.09 | Ras signaling |
|---|---|---|---|
Fly gene | Human homologue | Z-score | Function |
drk | GRB2 | -3.73 | Ras signaling |
CG11294 | CART1 | -3.07 | Transcription factor |
gfzf | GSTT1 | -3.02 | Glutathione transferase |
Pvr | PDGF / VEGF | -2.92 | Receptor tyrosine kinase |
rl | MAPK1 | -2.80 | Ras signaling |
Sec61alpha | SEC61A2 | -2.66 | Protein secretion |
Rheb | RHEB | -2.52 | Tor signaling |
Nup44A | SEH1L | -2.47 | Nuclear pore |
Ras85D | KRAS | -2.30 | Ras signaling |
csw | PTPN11 (SHP-2) | -2.22 | Ras signaling |
CG9306 | NDUFB9 | -2.20 | Mitochondrial electron transport |
CG9300 | NOL11 | -2.15 | Sugar transporter |
fax | C6orf168 | -2.04 | Axonogenesis |
Dsor1 | MAP2K1 | -2.02 | Ras signaling |