The effect of missing value imputation on correlation with functional similarity. The Pearson correlation between the similarity of GI profiles and the similarity of GO annotations (measured using GO semantic similarity ) was computed for the original and imputed data in each of the available E-MAPs. (a) Results on the ChromBio E-MAP. (b) Results on the ER E-MAP. (c) Results on the RNA E-MAP. To avoid bias, imputation did not use function-related features.