Figure 5

Correlation of expression levels in different embryonic developmental origins with ER. Shown is the mean correlation of expression levels with ER (human-mouse), for regions belonging to five different embryonic developmental origins. The latter are ordered on the x-axis in accordance with their height on the cranial vertical axis during early embryonic stages (spinal cord is the lowest, and Forebrain [pallium] is the highest). As evident, these ER/expression correlations are ordered by their cranial vertical location (Spearman rank correlation of 0.9; P = 0.037). A similar result was observed when computing the ER using the human lineage (human-chimpanzee; Additional data file 10). ER, evolutionary rate.