Table 1 Differential expression of OCT4 and NANOG targets in RNAi experiments
From: Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET
Method for determining bound targets | Percent of differentially expressed OCT4 targets on OCT4 knockdown | Percent of differentially expressed NANOG targets on NANOG knockdown |
|---|---|---|
ChIP-chip only | 33.9% (390/1,151) | 21.4% (192/898) |
ChIP-PET only | 29% (114/393) | 14.8% (91/616) |
ChIP-chip + ChIP-PET | 70.3% (83/118) | 33.5% (73/218) |
Percent of regulated genes | Â | Â |
   Upregulated | 39.4% | 50.6% |
   Downregulated | 60.6% | 49.4% |