Figure 1

C. rodentium infection in adult susceptible inbred FVB mice and resistant outbred SW mice. (a) Significant weight loss was observed in infected FVB mice at 8 dpi (p < 0.05). Weight was normalized and expressed as percent change of initial baseline. Red and green indicate SW and FVB mice, respectively; open and filled bars represent uninoculated and infected mice, respectively. Values are mean ± standard error of the mean. (b) Fecal bacterial counts were similar in both lines of mice at 3 dpi, but FVB mice had higher bacterial shedding at 8 dpi (p < 0.05). Bacterial counts were log10 transformed. (c) FVB mice infected with C. rodentium developed colonic inflammation that was significantly more severe than the milder colitis in SW mice at 9 dpi (p < 0.0001). (d) Infected FVB and SW mice developed comparable hyperplasia at 9 dpi. Experimental groups included 20, 10, and 7 uninoculated control, 4 dpi, and 9 dpi FVB mice, respectively, and 16, 10, and 10 SW mice in the corresponding groups. Each symbol represents one animal; filled symbols in red or green represent SW or FVB mice selected for array analysis. Mean or median lines for each group are presented. *p < 0.05; **p < 0.01.