Table 2 Use of isolated versus outbred populations
From: Isolated populations and complex disease gene identification
Benefits of population isolates | Benefits of outbred populations |
|---|---|
Higher degree of LD | More affected individuals |
Less areas of very low LD ('holes') | More polymorphic markers |
Ability to map recessive genes | More opportunity for replication |
Fewer number of causative alleles | Â |
Good genealogical records | Â |
More uniform environment | Â |
Less migration | Â |
More standardized phenotyping | Â |
High participation rate in studies | Â |