Effects of CC subtraction. Frequency plots of selected cancer types on the backdrop of lung development (left panel) and ES cell differentiation (middle panel) are depicted before and after the dismissal of hundreds of CC regulated genes. The corresponding probability distributions can be viewed in Additional data files 9 and 10. The right panel shows the effects of this CC subtraction on all data sets, quantified as the difference of the early probability distribution slope value (UpE) before and after elimination of CC regulated genes. PEN versus ESEN = proliferating endometrium versus early secretory endometrium; PEN versus MSEN = proliferating endometrium versus mid secretory endometrium.