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Table 2 Aging-associated probe sets that are differentially expressed in wounds from elderly compared to young subjects

From: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly

Affy ID

Gene*

Gene (description)

Function

q-value

FC

Down-regulated probe sets (12)

     

   217496_s_at

IDE §

insulin-degrading enzyme

Wound fluid/resolution of insulin response

4.0E-06

-20.5

   210074_at

CTSL2 §

cathepsin L2

Lysosomal cysteine proteinase

3.8E-05

-15.5

   214131_at

SERPINB13

serpin peptidase inhibitor, clade B (ovalbumin), member 13

UV-responsive proteinase inhibitor

1.1E-03

-15.0

   214131_at

C12orf5

chromosome 12 open reading frame 5

Protection from DNA damage

1.1E-03

-12.8

   204733_at

KLK6 §

kallikrein 6 (neurosin, zyme)

Hormone regulated serine protease

1.4E-05

-11.9

   202179_at

BLMH §

bleomycin hydrolase

Alzheimer's-associated cysteine peptidase

2.1E-03

-11.8

   210338_s_at

HSPA8 §

heat shock 70 kDa protein 8

Aging-associated heat shock protein

9.9E-04

-10.6

   201849_at

BNIP3 §

BCL2/adenovirus E1B 19 kDa interacting protein 3

Mitochondrial apoptosis-inducing

2.7E-04

-10.1

   203328_x_at

IDE §

insulin-degrading enzyme

Wound fluid/resolution of insulin response

1.4E-05

-17.4

   203327_at

IDE §

insulin-degrading enzyme

Wound fluid/resolution of insulin response

7.0E-04

-9.3

   205016_at

TGFA §

transforming growth factor, alpha

IFN-induced/epidermal regeneration

1.0E-03

-8.5

   212907_at

SLC30A1

Solute carrier family 30 (zinc transporter), member 1

Zinc/calcium ion transporter

8.5E-04

-7.3

  1. *Genes in bold have been validated by qPCR. CyberT-derived multiple testing corrected q-value. Fold change (old/young). §Also estrogen-regulated (Table 1).