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Table 2 Aging-associated probe sets that are differentially expressed in wounds from elderly compared to young subjects

From: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly

Affy ID Gene* Gene (description) Function q-value FC
Down-regulated probe sets (12)      
   217496_s_at IDE § insulin-degrading enzyme Wound fluid/resolution of insulin response 4.0E-06 -20.5
   210074_at CTSL2 § cathepsin L2 Lysosomal cysteine proteinase 3.8E-05 -15.5
   214131_at SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 UV-responsive proteinase inhibitor 1.1E-03 -15.0
   214131_at C12orf5 chromosome 12 open reading frame 5 Protection from DNA damage 1.1E-03 -12.8
   204733_at KLK6 § kallikrein 6 (neurosin, zyme) Hormone regulated serine protease 1.4E-05 -11.9
   202179_at BLMH § bleomycin hydrolase Alzheimer's-associated cysteine peptidase 2.1E-03 -11.8
   210338_s_at HSPA8 § heat shock 70 kDa protein 8 Aging-associated heat shock protein 9.9E-04 -10.6
   201849_at BNIP3 § BCL2/adenovirus E1B 19 kDa interacting protein 3 Mitochondrial apoptosis-inducing 2.7E-04 -10.1
   203328_x_at IDE § insulin-degrading enzyme Wound fluid/resolution of insulin response 1.4E-05 -17.4
   203327_at IDE § insulin-degrading enzyme Wound fluid/resolution of insulin response 7.0E-04 -9.3
   205016_at TGFA § transforming growth factor, alpha IFN-induced/epidermal regeneration 1.0E-03 -8.5
   212907_at SLC30A1 Solute carrier family 30 (zinc transporter), member 1 Zinc/calcium ion transporter 8.5E-04 -7.3
  1. *Genes in bold have been validated by qPCR. CyberT-derived multiple testing corrected q-value. Fold change (old/young). §Also estrogen-regulated (Table 1).