Figure 2

Estrogen-regulated wound-healing-associated genes predominate in age-associated delayed healing. (a,b) Graphical representation of the relative proportions of genes significantly up- (a) or down- (b) regulated in wounds from elderly subjects. (c) The key overrepresented GO groupings (functionally conserved gene groups) corresponding to each chart segment, their involvement in cutaneous healing, and significance of over-representation (EASE derived p-value). The majority of genes in our enriched data set (Additional data file 1) are estrogen regulated and actively involved in cutaneous healing. Ontology groups in red are significantly overrepresented in genes down-regulated in wounds from elderly subjects while those in green are overrepresented in genes with increased expression in wounds from elderly subjects.