Figure 1

Effects of TSA on genomic regions associated with NUP93 in human cells. (a) Short-range changes in NUP93-associated regions that result from treatment with TSA (- and + TSA) are shown for a region of chromosome 7p (7p21.3). The associated regions are indicated as grey blocks in the lower part of the figure. The locations of the three genes present in 7p21.3 are indicated. Map data are from the March 2006 assembly (hg18) of the human genome. NUP93-associated sites, corresponding to the 5' and upstream regions of the gene AK027125 in untreated controls, are broadened in TSA-treated cells to include the 5' ends of the flanking genes RPA3 (whose expression is unchanged by TSA), and GLCCI1 (whose expression is upregulated by TSA). (b) Long-range changes in NUP93-associated regions that result from treatment with TSA are shown for a region of chromosome 7q. Grey and black regions on the chromosome indicate cytogenetic bands (G-band, black; R-band, grey). The blue and black bands under the chromosome indicate the positions of genes, as indicated to the left of the figure. Map data are from the March 2006 assembly (hg18) of the human genome. Adapted from [10].