Replication origin is adjacent to cdc6, and close to gene for DP1 in several euryarchaeal genomes. Orthologous genes are indicated in the same color. Each gene is denoted by the name of the protein it encodes (see the key at the bottom). The origins of replication (oriC) are shown as bubble-shaped replication intermediate sketches; solid lines are used when the origin has been identified experimentally, and broken lines are used when the origin has been predicted with in silico analyses. Species or cell lineages that have the same genomic environment are listed and the number of corresponding genomes is given in parentheses. White arrows correspond to additional functionally unrelated genes. Genes are not shown to scale.