|
Most biased in gain
|
Most biased in ratio
|
---|
|
Pair
|
Ratio
|
Forward no.
|
Reverse no.
|
Gain
|
Pair
|
Ratio
|
Forward no.
|
Reverse no.
|
Gain
|
---|
Set I (orthologous proteins
|
I→V
|
1.82
|
1,632
|
895
|
737
|
C→D
|
9
|
27
|
3
|
24*
|
of PLUT and SRUB)
|
I→L
|
1.85
|
1,195
|
647
|
548
|
I→D
|
8.5
|
34
|
4
|
30*
|
|
K→E
|
4.09
|
704
|
172
|
532
|
I→P
|
8.43
|
59
|
7
|
52*
|
|
K→R
|
2.06
|
856
|
416
|
440
|
K→D
|
6.35
|
438
|
69
|
369
|
|
K→D
|
6.35
|
438
|
69
|
369
|
I→R
|
6.18
|
105
|
17
|
88
|
|
E→D
|
1.39
|
1,214
|
874
|
340
|
L→D
|
4.46
|
107
|
24
|
83
|
|
G→D
|
2.43
|
485
|
200
|
285
|
K→P
|
4.38
|
140
|
32
|
108
|
|
S→A
|
1.53
|
818
|
534
|
284
|
K→E
|
4.09
|
704
|
172
|
532
|
|
S→D
|
2.56
|
438
|
171
|
267
|
L→W
|
4.08
|
49
|
12
|
37
|
|
N→D
|
2.45
|
431
|
176
|
255
|
M→P
|
3.43
|
48
|
14
|
34
|
|
K→Q
|
2.84
|
330
|
116
|
214
|
M→E
|
3.28
|
95
|
29
|
66
|
|
S→T
|
1.52
|
616
|
405
|
211
|
F→H
|
3.27
|
85
|
26
|
59
|
|
L→V
|
1.31
|
833
|
635
|
198
|
I→E
|
3.03
|
94
|
31
|
63
|
|
R→D
|
2.57
|
308
|
120
|
188
|
M→R
|
2.95
|
112
|
38
|
74
|
|
S→E
|
1.82
|
403
|
221
|
182
|
L→E
|
2.91
|
201
|
69
|
132
|
|
A→D
|
1.77
|
415
|
235
|
180
|
K→Q
|
2.84
|
330
|
116
|
214
|
|
K→A
|
2.47
|
287
|
116
|
171
|
K→G
|
2.74
|
167
|
61
|
106
|
|
L→R
|
2.65
|
252
|
95
|
157
|
L→R
|
2.65
|
252
|
95
|
157
|
|
K→T
|
2.64
|
230
|
87
|
143
|
K→T
|
2.64
|
230
|
87
|
143
|
|
R→E
|
1.39
|
497
|
357
|
140
|
R→D
|
2.57
|
308
|
120
|
188
|
Set II (orthologous proteins
|
K→E
|
5.19
|
306
|
59
|
247
|
K→D
|
8.56
|
214
|
25
|
189
|
of PPUT and HMAR1)
|
I→V
|
1.62
|
521
|
321
|
200
|
L→D
|
5.6
|
56
|
10
|
46
|
|
L→V
|
1.75
|
462
|
264
|
198
|
K→E
|
5.19
|
306
|
59
|
247
|
|
A→E
|
2.28
|
351
|
154
|
197
|
Q→D
|
5.11
|
189
|
37
|
152
|
|
K→D
|
8.56
|
214
|
25
|
189
|
K→S
|
4.92
|
59
|
12
|
47
|
|
A→D
|
2.93
|
264
|
90
|
174
|
H→D
|
4.44
|
80
|
18
|
62
|
|
Q→E
|
2.44
|
266
|
109
|
157
|
I→D
|
4.2
|
21
|
5
|
16
|
|
Q→D
|
5.11
|
189
|
37
|
152
|
I→Y
|
4
|
40
|
10
|
30
|
|
G→D
|
2.41
|
210
|
87
|
123
|
P→H
|
3.8
|
19
|
5
|
14
|
|
R→D
|
2.71
|
160
|
59
|
101
|
M→E
|
3.63
|
29
|
8
|
21
|
|
R→E
|
1.95
|
207
|
106
|
101
|
L→P
|
3.43
|
48
|
14
|
34
|
|
N→D
|
2.35
|
169
|
72
|
97
|
Y→D
|
3.38
|
27
|
8
|
19
|
|
E→D
|
1.25
|
429
|
343
|
86
|
K→T
|
3.29
|
102
|
31
|
71
|
|
S→T
|
1.46
|
249
|
170
|
79
|
C→A
|
3.24
|
81
|
25
|
56
|
|
S→D*
|
1.9
|
152
|
80
|
72
|
L→E
|
3.13
|
100
|
32
|
68
|
|
K→T
|
3.29
|
102
|
31
|
71
|
K→G
|
2.95
|
65
|
22
|
43
|
|
A→T
|
1.55
|
198
|
128
|
70
|
A→D
|
2.93
|
264
|
90
|
174
|
|
P→D
|
2.82
|
107
|
38
|
69
|
K→P
|
2.91
|
32
|
11
|
21
|
|
L→I*
|
1.25
|
349
|
280
|
69
|
P→D
|
2.82
|
107
|
38
|
69
|
|
L→E
|
3.13
|
100
|
32
|
68
|
I→E
|
2.75
|
44
|
16
|
28
|
Set III (orthologous proteins
|
I→V
|
2.23
|
3,368
|
1,513
|
1,855
|
C→Q
|
10.00
|
30
|
3
|
27*
|
of MTHP and HMAR1)
|
R→E
|
2.62
|
1,836
|
701
|
1,135
|
K→D
|
7.30
|
883
|
121
|
762
|
|
R→D
|
4.34
|
1,306
|
301
|
1,005
|
M→D
|
7.28
|
182
|
25
|
158
|
|
E→D
|
1.52
|
2,576
|
1,693
|
883
|
C→D
|
5.31
|
69
|
13
|
56
|
|
K→E
|
4.11
|
1,162
|
283
|
879
|
I→Q
|
5.10
|
148
|
29
|
119
|
|
I→L
|
1.70
|
2,087
|
1,230
|
857
|
M→Q
|
4.91
|
157
|
32
|
125
|
|
S→D
|
2.84
|
1,312
|
462
|
850
|
C→E
|
4.86
|
68
|
14
|
54
|
|
K→D
|
7.30
|
883
|
121
|
762
|
I→D
|
4.80
|
192
|
40
|
152
|
|
L→V
|
1.60
|
1,978
|
1,237
|
741
|
L→D
|
4.49
|
337
|
75
|
262
|
|
G→D
|
2.35
|
1,183
|
504
|
679
|
M→H
|
4.44
|
80
|
18
|
62
|
|
S→A
|
1.61
|
1,556
|
967
|
589
|
K→Q
|
4.42
|
407
|
92
|
315
|
|
S→E
|
2.00
|
1,054
|
527
|
527
|
R→D
|
4.34
|
1,306
|
301
|
1,005
|
|
R→A
|
2.14
|
978
|
458
|
520
|
K→E
|
4.11
|
1,162
|
283
|
879
|
|
R→T
|
3.10
|
740
|
239
|
501
|
K→G
|
4.04
|
331
|
82
|
249
|
|
L→A
|
2.11
|
946
|
448
|
498
|
C→N
|
4.00
|
32
|
8
|
24*
|
|
I→A
|
2.76
|
756
|
274
|
482
|
I→W
|
3.88
|
62
|
16
|
46
|
|
I→T
|
3.84
|
572
|
149
|
423
|
I→T
|
3.84
|
572
|
149
|
423
|
|
V→T
|
1.88
|
892
|
475
|
417
|
M→E
|
3.81
|
259
|
68
|
191
|
|
N→D
|
2.23
|
753
|
337
|
416
|
K→T
|
3.79
|
425
|
112
|
313
|
|
R→Q
|
2.45
|
697
|
284
|
413
|
W→D
|
3.69
|
48
|
13
|
35*
|
Set IV (orthologous proteins
|
I→V
|
2.58
|
3,584
|
1,389
|
2,195
|
K→D
|
12.93
|
1,461
|
113
|
1,348
|
of UMET and NPHA)
|
K→E
|
8.72
|
2,023
|
232
|
1,791
|
K→E
|
8.72
|
2,023
|
232
|
1,791
|
|
K→D
|
12.93
|
1,461
|
113
|
1,348
|
K→A
|
8.28
|
993
|
120
|
873
|
|
K→R
|
3.01
|
1,623
|
540
|
1,083
|
K→G
|
6.57
|
519
|
79
|
440
|
|
I→L
|
1.95
|
2,135
|
1,096
|
1,039
|
M→D
|
6.50
|
130
|
20
|
110
|
|
K→A
|
8.28
|
993
|
120
|
873
|
M→R
|
5.59
|
246
|
44
|
202
|
|
N→D
|
3.20
|
1,024
|
320
|
704
|
K→T
|
5.44
|
685
|
126
|
559
|
|
S→A
|
1.65
|
1,515
|
920
|
595
|
C→R
|
5.00
|
60
|
12
|
48
|
|
K→T
|
5.44
|
685
|
126
|
559
|
K→P
|
4.92
|
300
|
61
|
239
|
|
I→A
|
2.78
|
760
|
273
|
487
|
I→E
|
4.75
|
318
|
67
|
251
|
|
M→L
|
1.93
|
1,000
|
517
|
483
|
I→H
|
4.48
|
103
|
23
|
80
|
|
G→D
|
1.85
|
1,037
|
561
|
476
|
K→S
|
4.42
|
570
|
129
|
441
|
|
S→D
|
1.98
|
915
|
462
|
453
|
I→D
|
4.05
|
174
|
43
|
131
|
|
I→T
|
3.88
|
606
|
156
|
450
|
C→N
|
4.00
|
32
|
8
|
24*
|
|
K→S
|
4.42
|
570
|
129
|
441
|
K→Q
|
3.95
|
510
|
129
|
381
|
|
K→G
|
6.57
|
519
|
79
|
440
|
I→T
|
3.88
|
606
|
156
|
450
|
|
V→A
|
1.41
|
1,464
|
1,040
|
424
|
M→H
|
3.82
|
65
|
17
|
48
|
|
L→V
|
1.32
|
1,753
|
1,329
|
424
|
I→R
|
3.81
|
278
|
73
|
205
|
|
R→E
|
1.57
|
1,136
|
724
|
412
|
M→E
|
3.48
|
212
|
61
|
151
|
|
E→D
|
1.23
|
2,181
|
1,774
|
407
|
M→P
|
3.41
|
75
|
22
|
53
|
- All the replacements of amino acid pairs are significant at p < 10-3 for set I, p < 10-2 for set II, and p < 10-6 for sets III and IV, except replacements marked with asterisks. Organism abbreviations are listed in Table 1.