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Table 2 Pfam families with the highest and lowest SNP A/S ratios

From: Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective

Pfam accession A/S ratio Number of proteins Pfam description
PF05296 0.49 55 Mammalian taste receptor protein (TAS2R)
PF00001 0.49 558 7 transmembrane receptor (rhodopsin family)
PF02798 0.47 20 Glutathione S-transferase, amino-terminal domain
PF00043 0.46 24 Glutathione S-transferase, carboxy-terminal domain
PF01454 0.45 24 MAGE family
PF09723 0.44 42 Putative regulatory protein (CxxC_CxxC_SSSS)
PF02023 0.44 39 SCAN domain
PF00059 0.43 58 Lectin C-type domain
PF07859 0.42 21 alpha/beta Hydrolase fold
PF00048 0.40 23 Small cytokines (intecrine/chemokine), interleukin-8 like
PF00105 0.14 38 Zinc finger, C4 type (two domains)
PF00536 0.14 68 SAM domain (Sterile alpha motif)
PF07649 0.13 45 C1-like domain
PF00125 0.13 25 Core histone H2A/H2B/H3/H4
PF00535 0.13 27 Glycosyl transferase family 2
PF01437 0.13 31 Plexin repeat
PF00335 0.13 23 Tetraspanin family
PF00350 0.12 28 Dynamin family
PF07707 0.11 36 BTB And C-terminal Kelch
PF00433 0.09 33 Protein kinase C terminal domain
  1. Top part: ten families with the highest A/S ratios. Bottom part: ten families with the lowest A/S ratios.