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Table 5 Transcriptional regulatory global models constructed for the five embryonic development sets

From: ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?

Development process Key transcription factors and binding sites in TRGM (weight)
Primary heart field D type LTRs (1.12), HAND1/TCF3 (1.01), STAT3 (0.92), STAT5A (0.89), GATA1/GATA2 (0.63), ELK1 (0.32)
Secondary heart field HNF3α (1.56), STAT5A/STAT5B (1.00), GATA2 (0.56), NFAT (0.56), GATA/GATA3 (0.48), WHN (0.35)
Neural crest cells FREAC-7 (1.00), Poly A (1.00), TBX5 (1.00), HSF (0.89), FREAC-2 (0.30)
Eye development RREB1 (1.00), IRF (0.96), POU3F2 (0.92), ZF5 (0.80), GATA/GATA1 (0.46), LMO2 (0.39), NKX6-1 (0.32)
Limb development TEF (1.00), PLZF (1.00), PAX4 (0.96), EGR (0.87), AP-2 (0.65), PBX (0.63), Ikaros 1 (0.37)
  1. TRGM, transcriptional regulatory global model.