Functional diversification of duplicate genes through subcellular adaptation of encoded proteins

Table 3 Comparison between the number of different compartments per D-pairs, proteins in D-pairs, and singleton proteins from the same GO categories

	Singleton		D-protein			D-pair
Biological process*	Total no.	Average no. of compartments	Total no.	Average no. of compartments	P-value^†	Total no.	Average no. of compartments	P-value^‡
Regulation of biological process	64	1.30	59	1.56	0.020	32	2.31	1.92E-10
Macromolecule metabolic process	247	1.28	98	1.54	0.001	52	2.31	1.57E-19
Cell organization and biogenesis	160	1.28	57	1.60	0.021	37	2.38	2.27E-14
Primary metabolic process	325	1.30	110	1.52	0.005	57	2.28	1.93E-20
Catabolic process	53	1.47	32	1.41	0.370	16	2.19	1.19E-04
Establishment of localization	81	1.17	33	1.55	0.013	19	2.37	1.82E-09
Biosynthetic process	162	1.30	32	1.53	0.044	18	2.11	1.52E-07
Cellular metabolic process	372	1.32	120	1.52	0.006	62	2.27	1.42E-21
Regulation of biological process	64	1.30	59	1.56	0.020	32	2.31	1.92E-10

The data are derived from 8 categories with at least 30 proteins per group - see text for details. *GO level 3. ^†Mann-Whitney U test comparing D-proteins and singletons. ^‡Mann-Whitney U test comparing D-pairs and singletons.

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