Figure 4
From: SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays
Effect of the location of probes for BIRC5 gene (synthetic data). (a) Effect of the location of the probes on the estimation of relative transcript concentrations. The y-axis shows the MAE (%) between simulated and estimated relative concentration of transcripts. The x-axis shows the different location of probes along the transcripts of the gene. J: the gene is represented by all its junction probes; E: the gene is represented by exon probes located in all its exons; J_E: all junction and exon probes are present in the array; J_2E or J_3E: all junctions and two or three probes per exon, respectively, are present in the array. (b) Effect of the location of the probes on splicing structure prediction. The y-axis shows the Hamming distance error rate between real and predicted pre-mRNA splicing structures. (c) Sensitivity of SPACE with varying location of the probes. (d) Specificity of SPACE with varying location of the probes.