Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Table 3 Dysregulated transcription factors in APL

Gene ID	Symbol	Gene name	APL expression	SAM score
20851	Stat5b	signal transducer and activator of transcription 5B	Up	12.05
14281	Fos	FBJ osteosarcoma oncogene	Up	9.71
11908	Atf1	activating transcription factor 1	Up	9.68
71371	Arid5b	AT rich interactive domain 5B (Mrf1 like)	Up	9.63
20181	Rxra	retinoid X receptor alpha	Up	9.48
17865	Mybl2	myeloblastosis oncogene-like 2	Down	-9.47
18046	Nfyc	nuclear transcription factor-Y gamma	Down	-10.21

SAM was used to identify seven TFs that are differentially expressed in APL and in normal promyelocytes. Five of these TFs are upregulated in APL, while two of them are downregulated.

ISSN: 1474-760X