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Table 4 Biological functions of novel predicted HNF4α gene targets

From: Genome wide prediction of HNF4α functional binding sites by the use of local and global sequence context

Gene symbol

Gene name

Biological function

CD63

CD63 antigen (melanoma 1 antigen)

Localization plasma membrane

  

Endocytosis

CHEK1

CHK1 checkpoint homolog

Cell cycle

  

Negative regulation of cell proliferation

  

DNA damage response

ESRRBL1

estrogen-related receptor beta like 1

Induction of neuronal apoptosis

DDB1

damage-specific DNA binding protein 1, 127 kDa

DNA repair

NCOA2

nuclear receptor coactivator 2

Regulation of transcription

  

Signal transduction

RND2

Rho family GTPase 2

Signal transduction

  

Protein transport

  

Dendrite development

SH3GL2

SH3-domain GRB2-like 2

Central nervous system development

  

Signal transduction

  

Endocytosis

TFF2

trefoil factor 2

Defense response

  

Digestion