Skip to main content
Figure 4 | Genome Biology

Figure 4

From: Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Figure 4

Frequency of nonsynonymous change as a function of distance from the exon-intron boundary. Amino acids are significantly more likely to be conserved near the exon-intron boundary comparing (a) C. elegans-C. briggsae (5', rho = 0.957, P = 0; 3', rho = 0.96. P = 0; N = 19,347 exons) and (b) D. melanogaster-D. pseudoobscura (5', rho = 0.87, P = 1.02E-07; 3', rho = 0.95, P = 0; N = 7,545 exons). The trends appear approximately monotonous and linear. Location-dependent conservation levels also appear slightly higher near the boundary comparing (c) S. cerevisiae-S. castellii but this is not significant (5', rho = 0.11, P = 0.55, N = 51; 3', rho = 0.11, P = 0.55, N = 39; pooled 3'/5', rho = 0.12, P = 0.51, N = 90) or of comparable monotony (but see Additional data file 9).

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us