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Table 1 MYCN/c-MYC target genes overexpressed in stage 4s-NA compared to localized-NA tumors (classes 1 and 2)

From: Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

Probe Gene name Class BMU Group MYCN/c-MYC-fold change* c-MYC target DB Validated by ChIP
A_24_P311604 C4orf28 1 195 I 1.38   +
A_23_P102420 CCT4 1 168 I 1.31   +
A_23_P5551 NCL 1 308 II 1.69 Up +
A_23_P44836 NT5DC2 1 140 I 1.40   +
A_32_P139196 C13ORF25V_1 2 308 II 3.83   ND
A_24_P133488 CDCA4 2 140 I 1.45   +
A_23_P137143 DKC1 2 308 II 1.93 Up +
A_23_P216396 EXOSC2 2 308 II 1.83   +
A_23_P78892 FBL 2 195 I 1.93 Up +
A_24_P228796 GAGE7B 2 195 I 1.27   ND
A_23_P41025 GNL3 2 308 II 1.80 Up ND
A_32_P8120 GNL3 2 308 II 1.81 Up ND
A_23_P398460 HK2 2 280 II 1.71 Up +
Hs172673.9 Hs172673.9 2 168 I 1.73   +
A_23_P502750 MDM2 2 336 II 1.19 ChIP +
A_23_P92261 MGC2408 2 280 II 2.14   +
A_23_P50897 MKI67IP 2 280 II 1.97 Up +
A_23_P214037 NPM1 2 140 I 1.61 Up +
A_23_P57709 PCOLCE2 2 308 II 2.40   +
A_24_P34632 PTMA 2 308 II 2.21 Up +
A_23_P126825 SLC16A1 2 195 I 1.22   +
A_23_P126291 SNRPE 2 336 II 1.49   +
A_23_P117068 SNRPF 2 336 II 1.44   +
A_23_P31536 SSBP1 2 336 II 1.24   +
A_23_P26810 TP53 2 140 I 1.44 Up +
  1. *Fold change expression in SH-EPMYCNcells after MYCN induction. c-MYC target gene database entry [25]: Up, upregulated; ChIP, validated by ChIP. Validation of MYCN/c-MYC binding using ChIP in this study (Additional data files 5-7). BMU, best matching unit; ND, not determined.