Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

Table 1 MYCN/c-MYC target genes overexpressed in stage 4s-NA compared to localized-NA tumors (classes 1 and 2)

Probe	Gene name	Class	BMU	Group	MYCN/c-MYC-fold change*	c-MYC target DB^†	Validated by ChIP^‡
A_24_P311604	C4orf28	1	195	I	1.38		+
A_23_P102420	CCT4	1	168	I	1.31		+
A_23_P5551	NCL	1	308	II	1.69	Up	+
A_23_P44836	NT5DC2	1	140	I	1.40		+
A_32_P139196	C13ORF25V_1	2	308	II	3.83		ND
A_24_P133488	CDCA4	2	140	I	1.45		+
A_23_P137143	DKC1	2	308	II	1.93	Up	+
A_23_P216396	EXOSC2	2	308	II	1.83		+
A_23_P78892	FBL	2	195	I	1.93	Up	+
A_24_P228796	GAGE7B	2	195	I	1.27		ND
A_23_P41025	GNL3	2	308	II	1.80	Up	ND
A_32_P8120	GNL3	2	308	II	1.81	Up	ND
A_23_P398460	HK2	2	280	II	1.71	Up	+
Hs172673.9	Hs172673.9	2	168	I	1.73		+
A_23_P502750	MDM2	2	336	II	1.19	ChIP	+
A_23_P92261	MGC2408	2	280	II	2.14		+
A_23_P50897	MKI67IP	2	280	II	1.97	Up	+
A_23_P214037	NPM1	2	140	I	1.61	Up	+
A_23_P57709	PCOLCE2	2	308	II	2.40		+
A_24_P34632	PTMA	2	308	II	2.21	Up	+
A_23_P126825	SLC16A1	2	195	I	1.22		+
A_23_P126291	SNRPE	2	336	II	1.49		+
A_23_P117068	SNRPF	2	336	II	1.44		+
A_23_P31536	SSBP1	2	336	II	1.24		+
A_23_P26810	TP53	2	140	I	1.44	Up	+

*Fold change expression in SH-EP^MYCNcells after MYCN induction. ^†c-MYC target gene database entry [25]: Up, upregulated; ChIP, validated by ChIP. ^‡Validation of MYCN/c-MYC binding using ChIP in this study (Additional data files 5-7). BMU, best matching unit; ND, not determined.

ISSN: 1474-760X